How can the same pathway create and destroy? What might our study of the Krebs cycle teach us about the mysteries of aging and the hardest problem of all, consciousness? Yet this same cycle, spinning in reverse, also created the chemical building blocks that enabled the emergence of life on our planet. Lane reveals the beautiful, violent world within our cells, where hydrogen atoms are stripped from the carbon skeletons of food and fed to the ravenous beast of oxygen. Transformer is Lane’s voyage, as a biochemist, to find the inner meaning of the Krebs cycle-and its reverse-why it is still spinning at the heart of life and death today. Lane is among the vanguard of researchers asking why the Krebs cycle, the “perfect circle” at the heart of metabolism, remains so elusive more than eighty years after its discovery. In Transformer, biochemist Nick Lane reveals a scientific renaissance that is hiding in plain sight -how the same simple chemistry gives rise to life and causes our demise. Our inheritance also includes our living metabolic network, a flame passed from generation to generation, right back to the origin of life. Information is important, but it is only part of what makes us alive. What brings the Earth to life, and our own lives to an end?įor decades, biology has been dominated by the study of genetic information.
He is one of my favorite science writers.”-Bill Gates “Nick Lane’s exploration of the building blocks that underlie life’s big fundamental questions-the origin of life itself, aging, and disease-have shaped my thinking since I first came across his work. From the renowned biochemist and author of The Vital Question, an illuminating inquiry into the Krebs cycle and the origins of life.
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